Research

Posters and Publications of the research I’ve done
ORCID: https://orcid.org/0000-0002-1872-7318


Yeo Lab (PhD) - Splicing mechanisms in translational medicine

I joined the Yeo Lab in October 2021. There are a lot of projects I’m working on, but my two major focuses are:

1) Collaborative project characterizing a nano-rare patient splicing mutation in sodium channel SCN8A. Our patient presents with pediatric epilepsy, and we’re developing antisense oligonucleotide treatments to treat the cause.


2) Developing a high-throughput screen that can be used to identify therapeutic regions-of-interest in splicing mutations/phenotypes. I’m looking at sodium channels for my thesis project, and determining the RNA-Binding-Proteins that regulate healthy and diseased splicing.

Carboard box with PCR strip tubes and green lab tape labels. The label reads "RNA 2024-03-18 HK"

Check out some of my previous research accomplishments!

  • Graduate Research Associate

    Brian Zid Lab, UC San Diego

    The Zid lab studies cell homeostasis and stress using biochemistry

    • Explored the effect of translational induction on mRNA localization during oxidative stress in mammalian cells

    • Created multiple biochemical assays and novel techniques to identify conserved sub-cellular behaviors between mammalian and yeast cells.

    • Developed method to stabilize fragile membrane-less compartments (p-bodies) for visualization by Fluorescence in-situ Hybridization.

    • Lead BSL2 mammalian cell culture division of lab, increasing project completion rate by 33%

    • Mentored two undergraduate students, one PhD candidate, and one Post-doctoral scholar in tissue culture experimental design/techniques.

  • Graduate Research Associate
    Roberto Malinow Lab, UC San Diego


    The Malinow lab studies the neural basis for depression in rats and humans

    • Hypothesized and found evidence of a dual-regulatory circuit between the Lateral Habenula and Lateral Preoptic Area

    • Characterized the habenular-circadian circuit as putatively having long-range GABA-ergic and Glutamatergic projections. Identified galanin expressing projections from the LPO to the LHb

    • Evaluated the behavioral effects of sub-anesthetic doses of ketamine on a conditional learned helplessness rodent model

    • Identified discrete populations of galanin and ketamine induced neuronal activity using Fluorescence in-situ Hybridization and Immunohistochemistry

    • Performed major and minor surgical operations on rodents (i.e. cranial injections, parafomaldehyde perfusions)

    • Presented work at Lewis Judd Young Investigators Symposium

  • Collaborated with Dr. Davidenko to continue face perception research from Bridgeman lab for publication

    • Designed, implemented, and analyzed experiments using Matlab software

    • Determined cognitive conflict between upper-visual-hemisphere bias and left gaze bias in facial perception

    • Wrote and revised manuscript for gaze bias Perception publication

  • Laboratory Manager, Undergraduate Research Assistant

    Bruce Bridgeman Lab, UC Santa Cruz

    The Bridgeman lab studied the psychophysics visual cognition

    • Designed, developed, and implemented multi-modal experiments using human eye-tracking

    • Created analysis informatics scripts using Python and Matlab

    • Instituted formal laboratory procedure for data recording across multiple researchers

    • Determined spatial memory of angled distances using closed-loop walking

    • Identified left-gaze bias through a facial perception study

    • Determined cognitive load using cross-modal attentional bias experiments.

    • Submitted closed-loop research for publication

    • Closed lab after the passing of Dr. Bridgeman

  • Undergraduate Research Assistant

    Carrie Partch Lab, UC Santa Cruz

    The Partch Lab studies the molecular clock using biochemistry

    • Identified Cancer-Testis antigen PASD1 as a circadian repressor

    • Developed circadian reporter lines from cancer cells

    • Developed novel circadian reporter line in suspension cells

    • Created siRNA knock-out systems using lentiviral mechanisms

    • Trained and instructed one graduate rotation student and two undergraduate researchers

    • Utilized persuasive writing and presentation skills in meetings and conferences

    • Developed grant proposal writing skills

    • Managed multiple research projects, coursework, and extracurricular activities simultaneously

    • Mastered mammalian cell culture protocol and techniques

    • Developed independent hypothesis of ALK5 receptor function and prospectus

Zid Lab — Stress GRanules

Glyoxal as an effective fixative for membrane-less granules in mammalian cells


Malinow Lab — Ketamine & Lateral Habenula

Posited the existence of a dual-regulation circuit mediating LHb activity through circadian neuropeptide regulation and acute neurotransmitter modulation in a depressed rodent model


Partch lab — PASD1

Developed a novel circadian reporter line. Characterized the cancer-testis antigen PASD1 as having peripheral circadian activity

K562 overlayed with 3T3.png

VSS 2016 Lateral Gaze Bias.jpg

Bridgeman Lab — Left Gaze Bias

Exploring the cognitive basis for the lateral gaze bias in human subjects

Slopes.jpg

Bridgeman Lab — Slopes

Provided evidence discouraging “effort hypothesis” of slope perception

Bridgeman B, Kopalle H. Open-loop locomotion on slopes. Perception; under review March 2016

prelim fig4.jpg

Davidenko Lab — Face Perception

Identifying the Left and Upper gaze biases of face perception